St. Ignatius Church at Chapel Point was founded in 1641 by Father Andrew White, a prominent English Jesuit, who was born in London in 1579 and who was one of the first Jesuits to arrive in Maryland.

In England, Catholics were forbidden to practice their faith. They couldn’t hold office, and many unbearable restrictions were put upon them. In the late 1620's, the Calvert family provided a plan for the colonization of Maryland; a new colony in the new world with freedom of religion possible for all. In November of 1633, the expedition set sail for America in two ships, the Ark and the Dove, with Fr. White among the colonists along with two other Jesuits, Fr. John Altham and Brother Thomas Gervase. The two ships arrived at St. Clement's Island in March 1634. Fr. White celebrated the first Mass in Maryland and set about establishing the Church in this new land.

Catholic settlers began to move westward along the Potomac River. Fr. White established a claim for St. Thomas Manor lands and took up his residence. A chapel had been erected at the point of land now known as Chapel Point. Fr. White labored among the Indians, broke the language barrier, and wrote a catechism in their language. The window above the entrance of the Church commemorates the baptism of the Indian King and Queen of the Piscataways. Fr. White also blessed their marriage, and baptized their child.

Father John G. Shea, S.J., an authority on U.S. Catholic history, tells of a remarkable miracle wrought through the large relic of the True Cross which Father White carried in a specially designed receptacle hung around his neck. Fr. White was called to attend an Indian who had been impaled by the limb of a tree. The branch had gone through the upper part of his body and he was in great agony and near death. Fr. White was able to impart the necessary articles of faith, which the Indian accepted, and then baptized him and administered the last Sacraments. Leaving instructions that, upon death, the body was to be kept for burial with the Church’s ritual, he blessed the Indian with the relic of the True Cross, and departed.

The next day, Fr. White returned to bury the Indian and was astonished to find the Indian recovered and out fishing. Two small marks were all that was left of the wounds. The same relic of the True Cross which Fr. White brought to America remains at the Church.

In 1645, Fr. White was captured, sent back to England in chains, and tried for being a Catholic priest and for having entered England illegally. He was acquitted but banished, and never returned to Maryland.

In 1649, Fr. Thomas Copley acquired 4,000 acres along the Port Tobacco River under Lord Baltimore’s "conditions of plantation," in exactly the same way as lands were obtained by other settlers. The Manor had been established and the claim entered by Fr. White in 1641. Fr. Copley assigned his rights to the land to Mr. Thomas Matthews, Esq. Mr. Matthews held the land in trust until 1662 when he conveyed all his rights to Fr. Henry Warren, S.J., the then resident pastor.

Fr. Warren was also Superior of the Maryland Mission and, until 1832, St. Thomas Manor was known as "The Superior’s Residence."

During the suppression of the Society of Jesus (1773 to 1805), the Jesuits continued their work at the Maryland Mission as secular priests. On August 18, 1805, the restoration of the Society took place at St. Thomas Manor. Fathers Robert Molyneux, S.J., Charles Sewall, S.J., and Charles Neale, S.J., renewed their vows here, thus becoming the first Jesuits of the new United States.

Among the strong and determined frontier priests to serve in Charles County were Fathers George Hunter, Ignatius Matthews, Charles and Francis Neale, Aloysius Mudd, and James Brent Matthews. All were from Charles County, with the exception of Fr. Hunter, who came from England. Fathers Charles and Francis Neale, and Fr. Ignatius Matthews had been parishioners of St. Ignatius, Chapel Point.

Fr. Bernardine F. Wiget, S.J. opened a school for boys in 1855. He was appointed to other work in 1856 and due to the scarcity of men teachers, the school closed in 1857. In 1870, a school for girls was established by the Misses Jennie and Nellie Neale. It continued until 1900.